e-book Cardiovascular Genomics: Methods and Protocols

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It is an introduction for the nonspecialist who will be performing complex experiments and laboratory work. Features: Topics include basic and fundamental laboratory techniques in molecular biology. These areas include cytogenetics, linkage analysis, cloning, and chromosomal substitution.

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In addition, there are two sections that apply to very specific aspects of cardiology: congenital long QT syndromes and genome-wide myocardial infarction risk factor screening. Assessment: This collection should prove to be an invaluable resource for acquainting new laboratory members with this field and maximizing their early productivity. These discussions and the accompanying straightforward protocols should be very helpful and comforting to a novice approaching what can be daunting tasks. You may be trying to access this site from a secured browser on the server.

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Next Steps in Cardiovascular Disease Genomic Research—Sequencing, Epigenetics, and Transcriptomics

Chromosome Substitution Strains. Annie E.

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    Back Matter Pages About this book Introduction Cardiovascular disease is the leading cause of death in developed countries, but is quickly becoming an epidemic in such well-populated countries as China, India, and other developing nations. Cardiovascular research is the key to the prevention, diagnosis, and management of cardiovascular disease.

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    Vigorous and cross-disciplinary approaches are required for successful card- vascular research. As the boundaries between different scientific disciplines, particularly in the life sciences, are weakening and disappearing, a successful investigator needs to be competent in many different areas, including genetics, cell biology, biochemistry, physiology, and structural biology.

    Mini Review ARTICLE

    The newly developed field of molecular medicine is a cross-disciplinary science that seeks to comprehend disease causes and mechanisms at the molecular level, and to apply this basic research to the prevention, diagnosis, and treatment of diseases and disorders. This volume in the Methods in Molecular Medicine series, C- diovascular Disease, provides comprehensive coverage of both basic and the most advanced approaches to the study and characterization of cardiovascular disease. These methods will advance knowledge of the mechanisms, diagnoses, and treatments of cardiovascular disease.

    Cardiovascular Disease is a timely volume in which the theory and pr- ciples of each method are described in the Introduction section, followed by a detailed description of the materials and equipment needed, and step-by-step protocols for successful execution of the method. A notes section provides advice for potential problems, any modifications, and alternative methods.